Acne

Acne

Hyperactivity of sebaceous glands - androgen stimulation increases sebum secretion by 300%

Abnormal keratinization of hair follicles - increased proliferation rate of keratinocytes by 2.5 times

Microbial colonization - Propionibacterium acnes density>10 ^ 5 CFU/cm ²

Inflammatory response - elevated levels of IL-1 α leading to hair follicle wall rupture

Hormonal fluctuations - peak testosterone levels increase by 80% during premenstrual period

Acne, as a common skin condition, is based on sebum keratin embolism of hair follicle sebaceous gland units. Its clinical manifestations include acne (open/closed) and inflammatory papules and other skin lesions.